博士风采

廖志勇

基本信息:

姓名:廖志勇

专业技术职务:教授

最高学历/学位:博士研究生/博士

联系地址:浙江省温州市茶山高教园区温州大学生环学院

邮编: 325035

联系电话: 0577-86599737

Email:zyliao@wzu.edu.cn

教育经历:

1994-1998:江西师范大学化学系,化学教育专业,学士

1998-2003:中科院上海生科院生化与细胞研究所,生物化学与分子生物学专业,博士

2005-2007:美国国家卫生研究院癌症研究所(NIH/NCI),博士后

工作经历:

2004-2007:江西师范大学生命科学学院,助理教授

2008-2013:亚博国际app,副教授,系主任(2009-2012

2009-2011:平阳县科技局,局长助理(挂职)

2014-至今:亚博国际app,教授

2015-2018:温州大学科技处,副处长(挂职)

2018-至今:亚博国际app,跟岗亚博国际app院长

社会兼职与人才称号:

中国生物化学与分子生物学会农业分会常务理事、中国生物化学与分子生物学会教学委员会青年委员、中国生物工程学会转化医学分会副秘书长、浙江省生物化学与分子生物学会理事、浙江省"151"人才,浙江省高校优秀青年教师。

主要研究方向:

1、水生动物(中华鲟、大鲵等)病原体感染时的免疫应答研究;

2、药用动植物活性化合物的分离、改造与活性研究;

承担科研项目:

1.苦荞种质资源在华东生态区的性状评价、活性成分挖掘及饲草开发与推广(项目编号:YS2017YFGH001734)。国家重点研发计划政府间国际科技创新合作重点专项课题.

2.大蓟黄酮类化合物挖掘、改造与抗糖尿病研究(项目编号:21276200)。国家自然科学基金.

3.抗原受体多样性的形成机制及其起源(项目编号:2013CB835300)。科技部973项目子课题.

4.中华鲟生长激素受体结构与功能及生长激素结合蛋白质产生机理的研究 (项目编号:30460036)。

国家自然科学基金.

5.温州近海特色鱼类养殖新型生物饲料的研发(项目编号:2012C33077)。浙江省科技厅社会公益项目.

6.丙型肝炎病毒新型检测试剂盒的研制(项目编号:2010C33173)。浙江省科技厅社会公益项目.

7.桦木醇类新化合物抗肿瘤活性及作用机理研究(项目编号:Y20110853)。浙江省自然科学基金.

8.桦木醇类新化合物挖掘与抗肿瘤活性研究( 项目编号:Z2100435)。浙江省自然科学基金重点项目.

9.羊栖菜新品种的选育和推广应用(项目编号:2015GA700005)。国家星火计划重点项目.

10.羊栖菜抗衰老多糖级分的筛选及抗衰老机制的初步研究(项目编号:31470430)。国家自然科学基金.

在温州大学发表研究论文:

1.Dongsong Nie.Hui Li.Yu Liu.Zhiyong Liao.Role of Spata34   in cell proliferation and its expression pattern in postnatal   development of rat testis.Molecular Biology Reports,2018 Oct 19.doi:   10.1007/s11033-018-4439-6.[Epub ahead of print]

2.Jiming Li,Jingjing   Zeng,Lianpin Wu,Luyuan Tao,Zhiyong Liao,Maoping Chu,Lei Li.Loss   of P53 regresses cardiac remodeling induced by pressure overload partially   through inhibiting HIF1α signaling in mice.Biochemical and Biophysical Research Communications2018,501: 394-399.

3.Fanfhua Gong,Zhiyong   Liao,Qiongzhen Chen.FGF1 improves functional recovery through inducing PRDX1   to reduce autophagy and ROS after spinal cord injury.Journal of Cellular and   Molecular Medicine 2018,22:2727-2738.

4.You Xiuling,Liu Liu,Li Xiuyu,Du Hejun,Nie Dongsong,Zhang Xu,Tong Haibing,Wu Mimgjiang,Gao Yitian,Liao Zhiyong.Immune response of   interferon-γ-inducible lysosomal thiol reductase (GILT) from Chinese sturgeon   (Acipenser sinensis) to microbial invasion and its antioxdative   activity in lipopolysaccharides-treated mammalian dentritic cells.Fish   Shellfish Immunology2018,72: 356-366.

5.Tong Haibing,Qi D,Guan X,Jiang G,Liao Zhiyong,Zhang Xu,Chen Peichao,Li Nan,Wu   Mingjiang.

c-Abl   tyrosine kinase regulates neutrophil crawling behavior under fluid shear   stress via Rac/PAK/LIMK/cofilin signaling axis.Journal of Cell and   Biochemistry 2018,119: 2806-2817.

6.Li Xiuyu,Du Hejun,Liu Liu,You Xiuling,Wu Mingjiang,Liao Zhiyong.MHC   class II alpha,beta and MHC class II-associated invariant chains from   Chinese sturgeon (Acipenser sinensis) and their response to immune   stimulation.Fish Shellfish Immunology 2017,70:1-12.

7.Chen Peichao,He   Dan,Zhang Ya,Yang S,Chen L,Wang S,Zou Huixi,Liao Zhiyong,Zhang   Xu,Wu Mingjiang.Sargassum fusiforme polysaccharides activate   antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate   stress insult during aging.Food and Function 2016,7:4576-4588.

8.Jingjing Chu,Bolun   Hu,Zhiyong Liao,Xingguo Zhang.Copper- catalyzed three-component   tandem cyclization for one-pot synthesis of 1,4-benzothiazines.The Journal   of Organic Chemistry 2016,81: 8647-8652.

9.You   Xiuling,Sheng Jianghong,Liu Liu,Nie Dongsong,Liao Zhiyong.Three   ferritin subunit analogs in Chinese giant salamander (Andrias davidianus)   and their response to microbial stimulation.Molecular Immunology   2015,67: 642-651.

10.You Xiuling,Nie Dongsong,Qin Huaxia,Liu Liu,Chen Xiaojun,Liao Zhiyong.Cloning   and characterization of immune molecule CD9 homolog in Chinese giant salamander   (Andrias davidianus).Chinese Journal of Biochemistry and Molecular   Biology,2015,31: 397-407.

11.Liao Zhiyong,Chen Xiaojun,Nie Dongsong,Wang Jiajia,Wu Mingjiang.A RING finger protein   114  (RNF114) homolog from Chinese sturgeon (Acipenser sinensis)   possesses immune-regulation properties via modulating RIG-I signaling   pathway-mediated interferon expression.Fish Shellfish Immunology 2014,41:   507-516.

12.Bolun Hu,Chunlin Li,Zhiyong   Liao,Xingguo Zhang.Tetrabutylammonium bromide catalyzed tandem   addition/cyclization of o-aralkynylaryl aldehydes with   trimethyl(trifluoromethyl)silane: synthesis of trifluoromethyl group   containing phthalans.SYNLETT 2013,24: 2748-2750.

13.Liao Zhiyong,Wu   Zhihua,Wu Mingjiang.Cirsium japonicum flavones enhance adipocyte differentiation   and glucose uptake in 3T3-L1 cells.Biological & Pharmaceutical Bulletin   2012,35: 855-860.

14.Sudhanshu   Shukla,Ken-ichi Fujita,Qi Xiao,Zhiyong Liao,Susan   Gareld,Srinivasa M.Srinivasula.A shear stress responsive gene product   PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on   the cell surface.Apoptosis2011,16: 162-173.

15.Zhiyong Liao,Mingjiang Wu,Xiaoli   Chen.Anti-diabetic effect of flavones fromCirsium japonicum DCin   diabetic rats.Archives of Pharmacal   Research2010,33: 353-362.

16.Liao Zhiyong,Chen Xiaoli,Wu Mingjiang.Molecular cloning and   functional analysis of Chinese sturgeon (Acipenser sinensis) growth hormone   receptor.Science   in China C Life Science2009,52:911-921.

获奖或专利:

1微生物活性成分高效生物合成关键技术及应用。浙江省科学技术进步奖二等奖,2017.

2以中药为基质的药用真菌深层发酵及其活性成分的研究浙江省高校教学科研成果奖一等奖,2012.

3、一种浒苔香菇多糖复合物的制备方法(专利号:ZL201010260825.9。国家发明专利,2012.

近三年指导学生竞赛:
1、浙江省第十届大学生生命科学竞赛一等奖。(学生:卢豆豆等;指导老师:王圣钦、廖志勇)

2、浙江省第九届大学生生命科学竞赛二等奖。(学生:苏婷婷等;指导老师:廖志勇)

3、浙江省第九届大学生生命科学竞赛三等奖。(学生:沈姜宏等;指导老师:廖志勇)

4、浙江省第十二届"挑战杯"大学生课外学术科技作品竞赛三等奖(学生:尤修玲;指导老师:廖志勇)

主讲课程:

1、本科生《生物化学》

2、研究生《化学生物学》

招生:

诚邀对分子药理学、细胞免疫学等研究方向感兴趣的同学(本科和硕士)加盟。

Curriculum Vitae

Zhiyong Liao   Ph.D

Professor

College for Life and Environmental Science

WenzhouUniversity

Cha-Shan University Town

Wenzhou325035

China

Tel: 86-577-86597351;Fax: 86-577-86689257

Email:zyliao@wzu.edu.cn

Education and job experience

1994-1998:  Department of Chemistry,Jiangxi Normal University,China.B.S

1998-2003:  College of Life Sciences,Shanghai Institute of Biochemistry andCell Biology,Chinese Academy of Sciences.Ph.D

2004-2005:  College of Life Sciences,Jiangxi Normal University.Assistantprofessor

2005-2007:  National Institute of Health,National Institute of Cancer,USA,Postdoctor

2008-2013:  College of Life and Environmental Science,Wenzhou University,Associate professor

2014-present: College of Life and Environmental Science,Wenzhou University,Professor

Research interests:

[1] Isolation of bioactive compounds from medicinal plants and animals and pharmacological research,such as anti-diabetic,anti-tumor and anti-aging.

[2] Identification,cloning,expression,structure and function of metabolism- or immune response-related genes from medicinal plants and animals.

[3]  Breeding and improvement of medicinal plants and animals.

Research projects:

[1] Character evaluation of tartary buckwheat germplasm resources in East China ecological region,active ingredient excavation,forage development and promotion.National Key R&D Program Intergovernmental International Science and Technology Innovation Cooperation Key Project (Grant No: YS2017YFGH001734),2019.01-2022.12.

[2] Screening of theSargassum fusiformepolysaccharide fractions with anti-aging effect and preliminary study on anti-aging mechanism.Funded by National Natural Science Foundation of China (Grant No: 31470430),2015.01-2018.12.

[3] Excavation,transformation and anti-diabetic effects of flavonoids fromCirsium japonicum.(Grant No: 21276200),2013.01-2016.12.

[4]  The formation mechanism of antigen receptor diversity and its origin.Funded by the National Basic Research Program of China (Grant No: 2013CB835301),2013.01-2017.08.

[5]  Study on the excavation and antitumor activity of new birch alcohols.(Grant No: Z2100435),2010.06-2013.06.

[6] Anti-tumor activity of novel Betulin compounds and the related functional mechanism.Funded by Natural Science Foundation of Zhejiang (Grant No: Y20110853),2011.01-2012.12.

[7] Development of novel diagnostic kit of Hepatitis C virus.Funded by Zhejiang Science and Technology Program (Grant No: 2010C33173),2011.01-2012.12.

[8] Structure and function of Chinese sturgeon growth hormone receptor and the mechanism through which growth hormone-binding protein is generated.Funded by National Natural Science Foundation of China (Grant No: 30460036),2005.01-2007.12.


Publications:

[1] Dongsong Nie.Hui Li.Yu Liu.Zhiyong Liao.Role of Spata34 in cell proliferation and its expression pattern in postnatal development of rat testis.Molecular Biology Reports,2018 Oct 19.doi: 10.1007/s11033-018-4439-6.[Epub ahead of print]

[2] Jiming Li,Jingjing Zeng,Lianpin Wu,Luyuan Tao,Zhiyong Liao,Maoping Chu,Lei Li.Loss of P53 regresses cardiac remodeling induced by pressure overload partially through inhibiting HIF1α signaling in mice.Biochemical and Biophysical Research Communications2018,501: 394-399.[4] Fanfhua Gong,Zhiyong Liao,Qiongzhen Chen.FGF1 improves functional recovery through inducing PRDX1 to reduce autophagy and ROS after spinal cord injury.Journal of Cellular and Molecular Medicine 2018,22:2727-2738.

[3]You Xiuling,Liu Liu,Li Xiuyu,Du Hejun,Nie Dongsong,Zhang Xu,Tong Haibing,Wu Mimgjiang,Gao Yitian,Liao Zhiyong.Immune response of interferon-γ-inducible lysosomal thiol reductase (GILT) from Chinese sturgeon (Acipenser sinensis) to microbial invasion and its antioxdative activity in lipopolysaccharides-treated mammalian dentritic cells.Fish Shellfish Immunology2018,72: 356-366.

[4] Tong Haibing,Qi D,Guan X,Jiang G,Liao Zhiyong,Zhang Xu,Chen Peichao,Li Nan,Wu Mingjiang.c-Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis.Journal of Cell and Biochemistry 2018,119: 2806-2817.

[5] Li Xiuyu,Du Hejun,Liu Liu,You Xiuling,Wu Mingjiang,Liao Zhiyong.MHC class II alpha,beta and MHC class II-associated invariant chains from Chinese sturgeon (Acipenser sinensis) and their response to immune stimulation.Fish Shellfish Immunology 2017,70:1-12.

[6] Chen Peichao,He Dan,Zhang Ya,Yang S,Chen L,Wang S,Zou Huixi,Liao Zhiyong,Zhang Xu,Wu Mingjiang.Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging.Food and Function 2016,7:4576-4588.

[7] Jingjing Chu,Bolun Hu,Zhiyong Liao,Xingguo Zhang.Copper- catalyzed three-component tandem cyclization for one-pot synthesis of 1,4-benzothiazines.The Journal of Organic Chemistry 2016,81: 8647-8652.

[8] You Xiuling,Sheng Jianghong,Liu Liu,Nie Dongsong,Liao Zhiyong.Three ferritin subunit analogs in Chinese giant salamander (Andrias davidianus) and their response to microbial stimulation.Molecular Immunology 2015,67: 642-651.

[9]Liao Zhiyong,Chen Xiaojun,Nie Dongsong,Wang Jiajia,Wu Mingjiang.A RING finger protein 114  (RNF114) homolog from Chinese sturgeon (Acipenser sinensis) possesses immune-regulation properties via modulating RIG-I signaling pathway-mediated interferon expression.Fish Shellfish Immunology 2014,41: 507-516.

[10] Bolun Hu,Chunlin Li,Zhiyong Liao,Xingguo Zhang.Tetrabutylammonium bromide catalyzed tandem addition/cyclization of o-aralkynylaryl aldehydes with trimethyl(trifluoromethyl)silane: synthesis of trifluoromethyl group containing phthalans.SYNLETT 2013,24: 2748-2750.

[11] Liao Zhiyong,Wu Zhihua,Wu Mingjiang.Cirsium japonicum flavones enhance adipocyte differentiation and glucose uptake in 3T3-L1 cells.Biological & Pharmaceutical Bulletin 2012,35: 855-860.
[12] Sudhanshu Shukla,Ken-ichi Fujita,Qi Xiao,Zhiyong Liao,Susan Gareld,Srinivasa M.Srinivasula.A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface.Apoptosis 2011,16: 162-173.

[13]Zhiyong Liao,Mingjiang Wu,Xiaoli Chen.Anti-diabetic effect of flavones fromCirsium japonicum DCin diabetic rats.Archives of Pharmacal Research2010,33: 353-362.

[14] Liao Zhiyong,Chen Xiaoli,Wu Mingjiang.Molecular cloning and functional analysis of Chinese sturgeon (Acipenser sinensis) growth hormone receptor.Science in China C Life Science2009,52:911-921.